B Brett Finlay Selected Research

Type III Secretion Systems

1/2018	Characterization of the two conformations adopted by the T3SS inner-membrane protein PrgK.
1/2015	Direct measurement of oxidative and nitrosative stress dynamics in Salmonella inside macrophages.
2/2014	Targeting the type III secretion system to treat bacterial infections.
6/2013	Global impact of Salmonella pathogenicity island 2-secreted effectors on the host phosphoproteome.
6/2012	Type III effector-mediated processes in Salmonella infection.
12/2011	The type III system-secreted effector EspZ localizes to host mitochondria and interacts with the translocase of inner mitochondrial membrane 17b.
12/2010	EseG, an effector of the type III secretion system of Edwardsiella tarda, triggers microtubule destabilization.
5/2008	Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS.
10/2007	Hierarchical delivery of an essential host colonization factor in enteropathogenic Escherichia coli.
2/2007	SseL is a salmonella-specific translocated effector integrated into the SsrB-controlled salmonella pathogenicity island 2 type III secretion system.

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B Brett Finlay Research Topics

Disease

74	Infections 06/2020 - 05/2002
16	Inflammation (Inflammations) 01/2019 - 06/2005
10	Bacterial Infections (Bacterial Infection) 06/2020 - 05/2007
10	Salmonella Infections (Salmonellosis) 01/2019 - 05/2004
6	Asthma (Bronchial Asthma) 01/2021 - 01/2015
5	Typhoid Fever (Typhoid) 02/2014 - 09/2004
5	Enterocolitis 01/2011 - 06/2005
4	Pneumonia (Pneumonitis) 01/2016 - 09/2008
4	Gastroenteritis 09/2015 - 04/2008
4	Colitis 11/2014 - 05/2006
4	Diarrhea 01/2014 - 05/2004
3	Malnutrition (Nutritional Deficiencies) 01/2022 - 10/2020
3	Neoplasms (Cancer) 01/2020 - 11/2014
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2019 - 01/2015
3	Communicable Diseases (Infectious Diseases) 01/2017 - 02/2011
3	Severe Acute Respiratory Syndrome 06/2013 - 03/2006
2	Overnutrition 01/2021 - 01/2021
2	Hypersensitivity (Allergy) 11/2020 - 11/2013
2	Growth Disorders 01/2020 - 01/2018
2	Fibrosis (Cirrhosis) 01/2019 - 03/2008
2	Leprosy (Hansen's Disease) 06/2014 - 01/2013
2	Hyperplasia 05/2006 - 04/2003
1	Kwashiorkor 01/2022
1	Cytomegalovirus Infections (Inclusion Disease) 01/2022
1	Fatty Liver 01/2022
1	Parkinson Disease (Parkinson's Disease) 01/2021
1	Clostridium Infections 01/2021
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2020
1	Neuroinflammatory Diseases 01/2020
1	Tetanus 01/2017
1	Gram-Positive Bacterial Infections 05/2016
1	Cholera 10/2015
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2015
1	Lung Diseases (Lung Disease) 01/2015

Drug/Important Bio-Agent (IBA)

26	Proteins (Proteins, Gene)FDA Link 06/2020 - 05/2002
15	Type III Secretion SystemsIBA 01/2018 - 05/2004
14	Anti-Bacterial Agents (Antibiotics)IBA 11/2020 - 10/2008
11	Virulence Factors (Pathogenicity Factors)IBA 06/2020 - 04/2003
8	CytokinesIBA 01/2019 - 01/2006
6	Immunoglobulin A (IgA)IBA 01/2021 - 06/2004
6	VaccinesIBA 01/2018 - 03/2006
6	Streptomycin (Streptomycin Sulfate)FDA Link 01/2015 - 01/2008
5	Peptide Hydrolases (Proteases)FDA Link 06/2020 - 02/2004
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017 - 07/2004
4	Vancomycin FDA LinkGeneric 01/2015 - 04/2007
4	Peptides (Polypeptides)IBA 05/2012 - 02/2004
4	ChemokinesIBA 09/2011 - 05/2004
3	Hormones (Hormone)IBA 01/2014 - 03/2011
2	AllergensIBA 01/2022 - 11/2020
2	Volatile Fatty AcidsIBA 01/2021 - 01/2014
2	ProteomeIBA 06/2020 - 01/2017
2	Oxidoreductases (Dehydrogenase)IBA 01/2019 - 05/2002
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 12/2016
2	Antimicrobial PeptidesIBA 01/2017 - 02/2004
2	Metronidazole (Metric)FDA LinkGeneric 01/2017 - 01/2011
2	EnzymesIBA 01/2015 - 06/2014
2	AntibodiesIBA 01/2015 - 03/2006
2	CholesterolIBA 06/2014 - 10/2013
2	InflammasomesIBA 02/2014 - 05/2012
2	Phosphotransferases (Kinase)IBA 06/2013 - 05/2002
2	CarbonIBA 09/2011 - 07/2007
2	P-SelectinIBA 09/2010 - 05/2009
2	P-selectin ligand proteinIBA 09/2010 - 05/2009
2	SelectinsIBA 09/2010 - 05/2009
2	L-SelectinIBA 09/2010 - 05/2009
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 09/2010 - 06/2005
2	Interleukin-6 (Interleukin 6)IBA 09/2010 - 07/2004
2	lambda Spi-1IBA 04/2008 - 11/2005
2	MetalsIBA 09/2004 - 05/2004
2	Messenger RNA (mRNA)IBA 11/2002 - 05/2002
1	MicronutrientsIBA 01/2022
1	16S Ribosomal RNAIBA 11/2020
1	protease SIBA 06/2020
1	Amino Acids FDA Link 06/2020
1	AminesIBA 06/2020
1	CaspasesIBA 06/2020
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 06/2020
1	aspartylglutamateIBA 06/2020
1	Docosahexaenoic AcidsIBA 01/2020
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2020
1	SphingolipidsIBA 01/2019
1	CeramidesIBA 01/2019
1	DisulfidesIBA 01/2019
1	Protease Inhibitors (Protease Inhibitor)IBA 01/2019
1	Biological ProductsIBA 01/2018
1	NeurotoxinsIBA 01/2017
1	Cefotaxime (Kendrick)FDA LinkGeneric 01/2016
1	OvalbuminIBA 01/2016
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2016
1	Cholera Vaccines FDA Link 10/2015
1	Actin Depolymerizing Factors (Cofilins)IBA 07/2015
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 05/2015
1	Plant ExtractsIBA 03/2015
1	PhytochemicalsIBA 03/2015

Therapy/Procedure

8	Therapeutics 01/2021 - 02/2011
2	Fecal Microbiota Transplantation 01/2021 - 01/2021
1	Mediterranean Diet 01/2021
1	Immunotherapy 01/2020
1	Precision Medicine 01/2020
1	Traditional Medicine (Folk Remedies) 03/2015